Antiphospholipid antibodies and Pregnancy Outcome of Assisted Reproductive Treatment

antibodyx

Antiphospholipid antibodies and Being pregnant Final result of Assisted Reproductive Therapy: A Systematic Assessment and Meta-analysis

Downside: Antiphospholipid antibodies (aPL) are a gaggle of autoantibodies related to a wide range of being pregnant problems, however the affect of aPL on the outcomes of assisted fertility remedy (ART) is controversial. This systematic evaluate and meta-analysis have been designed to discover the affiliation between aPL and ART outcomes and to discover by which phases does aPL play a task.

Methodology of research: PubMed and Cochrane database have been systematically retrieved, and odds ratios (ORs) or threat ratios (RRs) with 95% confidence intervals (CIs) have been calculated in a random-effect mannequin or fixed-effect mannequin in keeping with the heterogenicity assessed by the Cochran Q and I2 statistic take a look at. Of 246 data recognized by the search, 10 case-control research and 13 cohort research that explored the affiliation between aPL and in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) have been analyzed.

Outcomes: The outcomes confirmed that aPL optimistic charge was increased in females who failed in IVF/ICSI than those that succeeded in IVF/ICSI (OR: 3.62, 95% CI: 1.95-6.74). This research additionally indicated that females optimistic for aPL have a better miscarriage charge (RR: 1.68, 95% CI: 1.24-2.28) than these adverse for aPL, however reside start charge, biochemical being pregnant charge and medical being pregnant charge have been related between two teams (RR: 1.01, 95% CI: 0.91-1.12; RR: 1.18, 95% CI: 0.57-2.43 and RR: 0.95, 95% CI: 0.80-1.13).

 

Conclusions: There was increased aPL prevalence in females with antagonistic IVF/ICSI outcomes. Evidently aPL primarily impacts the miscarriage charge, however have little impact on reside start charge, biochemical being pregnant charge and medical being pregnant charge. Routine detection of aPL earlier than IVF/ICSI remedy is significant.

MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular choices as drug targets and antibody-drug conjugates for treatment

Superior colorectal adenocarcinoma (CRAC), featured by distinctive histopathological look, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a bunch of heterogeneous cancers with distinctive genetic signatures and malignant phenotypes. Remedy of CRAC is a daunting exercise for oncologists.

For the time being, quite a few strategies along with molecular specializing in using therapeutic monoclonal antibodies, small molecule kinase inhibitors and immunoregulatory checkpoint treatment have been utilized to struggle this deadly sickness. However, these therapeutic modalities and approaches acquire solely restricted success. Thus, there is a pharmaceutical wish to discover new targets and develop novel therapeutics for CRAC treatment. MET and RON receptor tyrosine kinases have been implicated in CRAC pathogenesis.

Scientific analysis have revealed that aberrant MET and/or RON expression and signaling are important in regulating CRAC growth and malignant phenotypes. Elevated MET and/or RON expression moreover has prognostic price for CRAC growth and affected particular person survival.

These choices current the rationale to concentrate on MET and RON for scientific CRAC intervention. At present, utilizing small molecule kinase inhibitors specializing in MET for CRAC remedy has achieved very important progress with quite a lot of approvals for scientific utility.

Nonetheless, antibody-based biotherapeutics, although beneath scientific trials for larger than Eight years, have made little or no progress. On this evaluation, we concentrate on the importance of MET and/or RON in CRAC tumorigenesis and development of anti-MET, anti-RON, and MET and RON-dual specializing in antibody-drug conjugates for scientific utility. The findings from every preclinical analysis and scientific trials highlight the potential of this novel sort of biotherapeutics for CRAC treatment eventually.

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Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)

TA501021 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4C3 (formerly 4C3)

TA501021S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)

TA501044 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4H1 (formerly 4H1)

TA501044S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)

TA501045 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)

TA501045S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)

TA501046 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)

TA501046S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)

TA501076 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11A6 (formerly 11A6)

TA501076S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)

TA501077 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B6 (formerly 11B6)

TA501077S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)

TA501078 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H5 (formerly 11H5)

TA501078S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)

TA501079 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11B5 (formerly 11B5)

TA501079S 30 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)

TA501080 100 µl Ask for price

Anti-NPR3 (Natriuretic Peptide Receptor C) mouse monoclonal antibody, clone OTI11H6 (formerly 11H6)

TA501080S 30 µl Ask for price

Monoclonal Anti-Cytokeratin Peptide 7 Antibody Antibody

GWB-BBB023 0.1 mg Ask for price

Monoclonal Anti-Cytokeratin Peptide 18 Antibody Antibody

GWB-BBB025 0.1 mg Ask for price

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse)

4-MAA503Mu21
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB)

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody

CAU30663-100ul 100ul
EUR 225.6

C-Type Natriuretic Peptide (CNP) Monoclonal Antibody

CAU30663-200ul 200ul
EUR 282.2

C-Peptide (CP) Monoclonal Antibody

CAU30505-100ul 100ul
EUR 247.7

C-Peptide (CP) Monoclonal Antibody

CAU30505-200ul 200ul
EUR 309.1

C-Peptide (CP) Monoclonal Antibody

CAU30630-100ul 100ul
EUR 245.8

C-Peptide (CP) Monoclonal Antibody

CAU30630-200ul 200ul
EUR 306.6

C-Peptide (CP) Monoclonal Antibody

CAU30193-100ul 100ul
EUR 254.4

C-Peptide (CP) Monoclonal Antibody

CAU30193-200ul 200ul
EUR 317.5

C-Peptide (CP) Monoclonal Antibody

CAU29243-100ul 100ul
EUR 267.8

C-Peptide (CP) Monoclonal Antibody

CAU29243-200ul 200ul
EUR 334.3

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC

4-MAA503Mu21-APC
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Cy3

4-MAA503Mu21-Cy3
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Cy3.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), HRP

4-MAA503Mu21-HRP
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with HRP.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), PE

4-MAA503Mu21-PE
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with PE.

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), FITC

4-MAA503Mu21-FITC
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with FITC.

Monoclonal Antibody to C-Type Natriuretic Peptide (CNP)

MAA721Hu22 100ul
EUR 235

Mouse Monoclonal Anti-Mouse/rat NOS-II/i-NOS peptide, ascites

INOS23-M 100 ul
EUR 578.4

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), APC-Cy7

4-MAA503Mu21-APC-Cy7
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with APC-Cy7.

Monoclonal RXRB Antibody (Hinge Peptide)

AMM02172G 0.05ml
EUR 580.8
Description: A Monoclonal antibody against Human RXRB (Hinge Peptide). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P

Monoclonal Antibody to C-Peptide (CP)

MAA447Po21 100ul
EUR 279

Monoclonal Antibody to C-Peptide (CP)

MAA447Ra21 100ul
EUR 258

Monoclonal Antibody to C-Peptide (CP)

MAA447Ra22 100ul
EUR 256

Monoclonal Antibody to C-Peptide (CP)

MAA447Ra23 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)

MAA447Ra24 100ul
EUR 264

Monoclonal Antibody to C-Peptide (CP)

MAA447Ra28 100ul
EUR 265

Natriuretic Peptides B Mouse Monoclonal Antibody

E10G20491 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody

E10G20492 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Natriuretic Peptides B Mouse Monoclonal Antibody

E10G20493 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Cytokeratin Peptide 18 Antibody ( Monoclonal, CY-90)

Ab1037 100μ/Vial
EUR 0.1

Anti-Cytokerain Peptide 7 Antibody (Monoclonal,LDS-68)

Ab1041 100μ/Vial
EUR 0.1

C-Peptide (CP) Monoclonal Antibody (Rat)

4-MAA447Ra21
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

C-Peptide (CP) Monoclonal Antibody (Rat)

4-MAA447Ra28
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP)

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody (Mouse), Biotinylated

4-MAA503Mu21-Biotin
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Description: A Rat monoclonal antibody against Mouse Natriuretic Peptide Precursor B (NPPB). This antibody is labeled with Biotin.

C-Peptide (CP) Monoclonal Antibody (Human)

4-MAA447Po21
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP)

Natriuretic Peptide Receptor B (NPR2) mouse monoclonal antibody, clone 1E4, Purified

AM31118PU-N 50 µg Ask for price

Mouse monoclonal anti-human Proteolipid protein peptide 139-151 IgG, aff pure

PLP139-M 100 ug
EUR 578.4

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU30640-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU30640-200ul 200ul
EUR 268.8

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29496-100ul 100ul
EUR 236.2

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29496-200ul 200ul
EUR 295.7

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29531-100ul 100ul
EUR 215

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29531-200ul 200ul
EUR 268.8

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29254-100ul 100ul
EUR 201.6

Brain Natriuretic Peptide (BNP) Monoclonal Antibody

CAU29254-200ul 200ul
EUR 252

Natriuretic Peptide Receptor B (NPR2) (131-231) mouse monoclonal antibody, clone 2A6, Purified

AM31133PU-N 50 µg Ask for price

Mouse Monoclonal Anti-Human Human Ki67 (Proliferation Marker) peptide IgG

KI672-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Rat), PE

4-MAA447Ra21-PE
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), PE

4-MAA447Ra28-PE
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with PE.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30508-100ul 100ul
EUR 267.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30508-200ul 200ul
EUR 334.3

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30514-100ul 100ul
EUR 221.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30514-200ul 200ul
EUR 277.2

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30210-100ul 100ul
EUR 267.8

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU30210-200ul 200ul
EUR 334.3

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU29329-100ul 100ul
EUR 225.6

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody

CAU29329-200ul 200ul
EUR 282.2

C-Peptide (CP) Monoclonal Antibody (Rat), APC

4-MAA447Ra21-APC
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3

4-MAA447Ra21-Cy3
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP

4-MAA447Ra21-HRP
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

C-Peptide (CP) Monoclonal Antibody (Rat), APC

4-MAA447Ra28-APC
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Rat), Cy3

4-MAA447Ra28-Cy3
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Rat), HRP

4-MAA447Ra28-HRP
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with HRP.

Monoclonal Natriuretic Peptide Receptor C Antibody, Clone: 1748CT403.18.42

AMM02573G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Natriuretic Peptide Receptor C. The antibodies are raised in Mouse and are from clone 1748CT403.18.42. This antibody is applicable in WB, E

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu21 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu22 100ul
EUR 210

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu23 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu24 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu25 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu27 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Hu29 100ul
EUR 217

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Mi28 100ul
EUR 293

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Mu21 100ul
EUR 246

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Ra21 100ul
EUR 253

Monoclonal Antibody to Brain Natriuretic Peptide (BNP)

MAA541Ra22 100ul
EUR 260

C-Peptide (CP) Monoclonal Antibody (Human), PE

4-MAA447Po21-PE
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC

4-MAA447Ra21-FITC
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Rat), FITC

4-MAA447Ra28-FITC
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with FITC.

C-Peptide (CP) Monoclonal Antibody (Human), APC

4-MAA447Po21-APC
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with APC.

C-Peptide (CP) Monoclonal Antibody (Human), Cy3

4-MAA447Po21-Cy3
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Cy3.

C-Peptide (CP) Monoclonal Antibody (Human), HRP

4-MAA447Po21-HRP
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with HRP.

Monoclonal Antibody to Glucagon Like Peptide 1 (GLP1)

MAA804Mi21 100ul
EUR 245

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat)

4-MAA541Mu21
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP)

Monoclonal Anti-Human/mouse/rat Insulin chain B peptide IgG, aff pure

INSB22-M 100 ul
EUR 578.4

C-Peptide (CP) Monoclonal Antibody (Human), FITC

4-MAA447Po21-FITC
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with FITC.

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU30487-100ul 100ul
EUR 255.4

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU30487-200ul 200ul
EUR 319.2

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU29569-100ul 100ul
EUR 227.5

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU29569-200ul 200ul
EUR 284.8

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU30352-100ul 100ul
EUR 248.6

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody

CAU30352-200ul 200ul
EUR 310.8

Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

MAA946Ge21 100ul
EUR 279

Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

MAA946Ge28 100ul
EUR 279

Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

MAA946Hu21 100ul
EUR 235

Monoclonal Antibody to Amyloid Beta Peptide 1-42 (Ab1-42)

MAA946Mi22 100ul
EUR 239

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human)

4-MAA541Hu22
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  • 20ul
Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP)

Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP)

MAA380Hu21 100ul
EUR 242

Monoclonal Antibody to Vasoactive Intestinal Peptide (VIP)

MAA380Hu22 100ul
EUR 235

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody

CAU30207-100ul 100ul
EUR 229.4

Natriuretic Peptide Precursor B (NPPB) Monoclonal Antibody

CAU30207-200ul 200ul
EUR 286.4

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat), PE

4-MAA541Mu21-PE
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  • 100ul
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP). This antibody is labeled with PE.

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated

4-MAA447Ra21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

C-Peptide (CP) Monoclonal Antibody (Rat), Biotinylated

4-MAA447Ra28-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with Biotin.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a)

4-MAA946Mi21
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  • 100ul
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42)

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human)

4-MAA946Hu21
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  • 100ul
  • 10ml
  • 1ml
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42)

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat), APC

4-MAA541Mu21-APC
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  • 100ul
  • 10ml
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP). This antibody is labeled with APC.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat), Cy3

4-MAA541Mu21-Cy3
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  • 100ul
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP). This antibody is labeled with Cy3.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat), HRP

4-MAA541Mu21-HRP
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  • 100ul
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP). This antibody is labeled with HRP.

C-Peptide (CP) Monoclonal Antibody (Human), Biotinylated

4-MAA447Po21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Human C-Peptide (CP). This antibody is labeled with Biotin.

Monoclonal Antibody to Cathelicidin Antimicrobial Peptide (CAMP)

MAC419Hu21 100ul
EUR 266

Monoclonal Antibody to Cathelicidin Antimicrobial Peptide (CAMP)

MAC419Hu22 100ul
EUR 259

Monoclonal Antibody to Cathelicidin Antimicrobial Peptide (CAMP)

MAC419Hu28 100ul
EUR 237

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human), PE

4-MAA541Hu22-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP). This antibody is labeled with PE.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Rat), FITC

4-MAA541Mu21-FITC
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  • 100ul
  • 10ml
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Description: A Rat monoclonal antibody against Rat Brain Natriuretic Peptide (BNP). This antibody is labeled with FITC.

Mouse Monoclonal Anti-Human Beta Actin peptide (non-muscle) IgG-HRP Conjugate

ACTB12-HRP 100 ul
EUR 489.6

Peptide YY (PYY) (Rat, Mouse, Porcine, Canine) - Antibody

H-059-03 100 μl
EUR 469.8

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human), APC

4-MAA541Hu22-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP). This antibody is labeled with APC.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human), Cy3

4-MAA541Hu22-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP). This antibody is labeled with Cy3.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human), HRP

4-MAA541Hu22-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP). This antibody is labeled with HRP.

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human, Pig)

4-MAA541Hu28
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  • 100ul
  • 10ml
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Description: A Mouse monoclonal antibody against Human, Pig Brain Natriuretic Peptide (BNP)

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a), PE

4-MAA946Mi21-PE
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with PE.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human), PE

4-MAA946Hu21-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with PE.

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody (Human)

4-MAC419Hu21
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Cathelicidin Antimicrobial Peptide (CAMP)

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody (Human)

4-MAC419Hu22
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Cathelicidin Antimicrobial Peptide (CAMP)

Cathelicidin Antimicrobial Peptide (CAMP) Monoclonal Antibody (Human)

4-MAC419Hu28
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Cathelicidin Antimicrobial Peptide (CAMP)

Mouse Monoclonal Anti-Human Myelin Oligodendrocyte Glycoprotein (35-55 aa) peptide IgG

MOG3555-M 100 ug
EUR 578.4

Monoclonal Antibody to Natriuretic Peptide Precursor B (NPPB)

MAA503Mu21 100ul
EUR 239

Brain Natriuretic Peptide (BNP) Monoclonal Antibody (Human), FITC

4-MAA541Hu22-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Brain Natriuretic Peptide (BNP). This antibody is labeled with FITC.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a), APC

4-MAA946Mi21-APC
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  • 100ul
  • 10ml
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with APC.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a), Cy3

4-MAA946Mi21-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with Cy3.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a), HRP

4-MAA946Mi21-HRP
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  • 100ul
  • 10ml
  • 1ml
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with HRP.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human), APC

4-MAA946Hu21-APC
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  • 100ul
  • 10ml
  • 1ml
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with APC.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human), Cy3

4-MAA946Hu21-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with Cy3.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human), HRP

4-MAA946Hu21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with HRP.

Monoclonal Antibody to Glutaminyl Peptide Cyclotransferase (QPCT)

MAH274Hu21 100ul
EUR 259

C-Peptide (CP) Monoclonal Antibody (Rat), APC-Cy7

4-MAA447Ra21-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC-Cy7.

C-Peptide (CP) Monoclonal Antibody (Rat), APC-Cy7

4-MAA447Ra28-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rat C-Peptide (CP). This antibody is labeled with APC-Cy7.

Monoclonal Anti-Human Gamma Tubulin peptide IgG

TUBG31-A 100 ul
EUR 578.4

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (n/a), FITC

4-MAA946Mi21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against n/a Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with FITC.

Amyloid Beta Peptide 1-42 (Ab1-42) Monoclonal Antibody (Human), FITC

4-MAA946Hu21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Amyloid Beta Peptide 1-42 (Ab1-42). This antibody is labeled with FITC.

Antibody Response to Canine Parvovirus Vaccination in Canines with Hyperadrenocorticism Dealt with with Trilostane

  • It is unknown how canines with hyperadrenocorticism (HAC) reply to vaccination. This analysis measured antibodies in opposition to canine parvovirus (CPV) in canines with HAC dealt with with trilostane sooner than and after CPV vaccination, and in distinction the immune response to that from healthful canines. Eleven canines with HAC, and healthful age-matched administration canines (n = 31) obtained a modified-live CPV vaccine.
  • Antibodies have been selected days 0, 7, and 28 by hemagglutination inhibition. Univariate analysis was used to match the immune response of canines with HAC and healthful canines.
  • Pre-vaccination antibodies (≥10) have been detected in 100% of canines with HAC (11/11; 95% CI: 70.0-100) and in 93.5% of healthful canines (29/31; 95% CI: 78.3-99.2). No ≥4-fold improve in antibody titer was seen in canines with HAC whereas in 22.6% of healthful canines, a ≥4-fold titer improve was seen (7/31; 95% CI: 11.1-40.1).
  • Mild vaccine-associated antagonistic events (VAAEs) have been detected in 54.5% of canines with HAC (6/11; 95% CI: 28.0-78.8) and in 29.0% of healthful canines (9/31; 95% CI: 15.9-46.8).
  • There was neither a very important distinction in presence of pre-vaccination antibodies (p = 1.000), or response to vaccination (p = 0.161), nor throughout the prevalence of VAAEs (p = 0.158). Immune carry out of canines with HAC dealt with with trilostane seems just like that of healthful canines.

Design and Validation of Linkers for Web site-Specific Preparation of Antibody-Drug Conjugates Carrying Quite a lot of Drug Copies Per Cysteine Conjugation Web site

First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are restricted to 1 drug per cysteine. However, certain functions require a extreme drug to antibody ratio (DAR), akin to when low-potency payloads are used. Elevated drug load could also be achieved using classical cysteine conjugation methods, nevertheless these result in heterogeneity, suboptimal efficacy and pharmacokinetics.

Proper right here, we describe the design, synthesis and validation of heterobifunctional linkers that may be utilized for the preparation of ADCs with a DAR of two, three and Four in a site-specific methodology per single cysteine conjugation web site, resulting in site-specific ADCs with a DAR of 4, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and quite a lot of cyclic diene moieties which could successfully react with maleimide-carrying payloads through the Diels-Alder response.

As a proof of concept, we synthesized site-specific DAR 4, six and eight ADCs carrying tubulysin (AZ13601508) using engineered antibodies with a cysteine inserted after place 239 throughout the antibody CH2 space.

We evaluated and in distinction the in vitro cytotoxicity of ADCs obtained by the use of the site-specific platform described herein, with ADCs prepared using classical cysteine conjugation. Our information validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with extreme drug load for therapeutic functions.

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